213 problems have been reported for the 2008 Mercedes Benz E350. The following chart shows the 20 most common problems for 2008 Mercedes Benz E350. The number one most common problem is related to the vehicle's fuel system, other with 77 problems. The second most common problem is related to the vehicle's seats (20 problems).
The following chart shows the number of problems reported during each of the service years since the debut of the 2008 Mercedes Benz E350 in 2008.
| Service Year | Number of Problems |
|---|---|
| 2026 | |
| 2025 | |
| 2024 | |
| 2023 | |
| 2022 | |
| 2021 | |
| 2020 | |
| 2019 | |
| 2018 | |
| 2017 | |
| 2016 | |
| 2015 | |
| 2014 | |
| 2013 | |
| 2012 | |
| 2011 | |
| 2010 | |
| 2009 | |
| 2008 |
When making the decision between buying a new or used Mercedes Benz E350, the following table can be used to compare the 2008 Mercedes Benz E350 with the Mercedes Benz E350 from other model years. Note that the number of problems reported for the 2008 E350 is 213 while the average number of problems reported for the 19 model years of the Mercedes Benz E350 is 139.