228 problems have been reported for the 2010 Mercedes Benz E350. The following chart shows the 19 most common problems for 2010 Mercedes Benz E350. The number one most common problem is related to the vehicle's air bags with 66 problems. The second most common problem is related to the vehicle's equipment (21 problems).
The following chart shows the number of problems reported during each of the service years since the debut of the 2010 Mercedes Benz E350 in 2010.
| Service Year | Number of Problems |
|---|---|
| 2026 | |
| 2025 | |
| 2024 | |
| 2023 | |
| 2022 | |
| 2021 | |
| 2020 | |
| 2019 | |
| 2018 | |
| 2017 | |
| 2016 | |
| 2015 | |
| 2014 | |
| 2013 | |
| 2012 | |
| 2011 | |
| 2010 |
When making the decision between buying a new or used Mercedes Benz E350, the following table can be used to compare the 2010 Mercedes Benz E350 with the Mercedes Benz E350 from other model years. Note that the number of problems reported for the 2010 E350 is 228 while the average number of problems reported for the 19 model years of the Mercedes Benz E350 is 139.