One problem related to wiring has been reported for the 2010 Mercedes Benz E350. The most recently reported issues are listed below.
A pint of orange juice spilled on the floor of the passenger side back seat. It was cleaned up, but apparently some of the juice was able to eventually make its way into the unprotected electrical connector located under the passenger seat floor well. This caused an electrical short. Actual burn marks in the wiring near the harness connector are clearly visible. Fortunately, there was no fire, and the only indication of a problem was that the air bag service light eventually came on.