One problem related to manual transmission has been reported for the 2000 Nissan Frontier. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Nissan Frontier based on all problems reported for the 2000 Frontier.
Main transmission rod (standard) had to be replaced at 130,000 miles and main throw out bearings had to be replaced at 100,000 miles. Both repairs were costly for a truck that was bought brand new and isnt even paid for yet. Nissan's have a reputation for lasting forever, but I guess we got a bad one.