One problem related to air conditioner has been reported for the 2016 Toyota Prius. The most recently reported issues are listed below.
The car's air conditioning system continually sets itself to the auto position and disables itself where nothing you do can activate the fan the air conditioning the heat anyting, going through all the menus resetting everything turning the car off and on 50 times does no good. This began happening when the car had about ten thousand miles on it and has been more and more common since.