One problem related to transmission failure has been reported for the 1999 Toyota Sienna. The most recently reported issues are listed below.
Transmission prematurely fails on 99 Sienna after 61k miles.
| Power Train problems | |
| Automatic Transmission problems | |
| Transmission Failure problems | |
| Transmission Noise problems | |
| Axle Shaft problems | |
| Vehicle Shudder problems |