One problem related to fuel injection rail has been reported for the 2001 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Toyota Sienna based on all problems reported for the 2001 Sienna.
Electrical system containing fuel injector relay failed. Fuel injector stopped working and car lost power on highway. Replacing relay and fuse by dealership did not fix problem, ended up failing again after being returned from dealership.