One problem related to radiator has been reported for the 2006 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Toyota Sienna based on all problems reported for the 2006 Sienna.
I was traveling at 65mph on interstate 90 east. The car while driving when I was giving gas it didnt run forward and it just stopped on the middle of the road with my kids in it. I took it to the dealer and dealer told me that the radiator pipe got corroded so the cooling oil from the transmission didnt flow properly and the transmission failed during the car running. The Toyota has safety recall of excessive corrosion for the spare tire then same thing applies as the corrosion part is underneath of the engine.