One problem related to engine failure has been reported for the 2010 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Toyota Sienna based on all problems reported for the 2010 Sienna.
The engine failed while entering the highway. All power was lost and vehicle had to be towed to the local Toyota dealer. I was informed today that in order to analyze the problem the engine needs to be removed at $140 per hour approx. 20 hrs of labor. I have given them permission to do this so I can receive a quote as to how much to repair. This Sienna was just in for 125,000 mile service with no known issues. I do not have any type of documentation as of today June 4,2018.