One problem related to universal joint has been reported for the 2001 Toyota Tundra. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Toyota Tundra based on all problems reported for the 2001 Tundra.
Design defect regarding drive shaft lubrication. The flange or base of the universal joint bearing overrides the base of the alemite fitting making it impossible to get a tight fitting. When attempting to lube the bearings the grease just squirts around the fitting and not in.