Four problems related to diesel engine have been reported for the 2006 Ford E-350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford E-350 based on all problems reported for the 2006 E-350.
Ford 6. 0 diesel engines have issues in respect to the seals on the oil pumps for the injection system. It is not a question of if the seals will fail, it's when. When the seals fail, the engine will shut down completely leaving the driver without power steering or brakes. I have two (2) vehicles fail in traffic causing the drivers to attempt to exit the roadway without being hit by another vehicle. The issue seems to be related to the "o-ring" seals used through-out the injection system. Unfortunately, I don't have the old parts available, but with approximately ten of these vehicles in our fleet, I'm sure it won't take long before another one fails. This effects all 6. 0 Ford diesel motors in all model vehicles from 2004-2008. I don't understand why there has not been a safety recall on all vehicles with this motor. As mentioned, it is not a question of if the engine will fail, but when.
2005 Ford E-350 egr valve problems, check engine light illuminated.
Vehicle had a very bad engine oil leak. Sent to woolwine Ford for repair. They failed to repair problem. Sent vehicle to butch ostalet Ford. Ford authorized them to install a new short block and they did. This engine leaks in the same place as the original engine.
Failure of injectors and internal oil cooler led to immediate engine shut down causing immediate loss of power steering, power brakes, etc. This happened on two separate occasions, (1 while driving on interstate during 8am morning traffic, 2 while towing a 5th wheel RV in heavy afternoon traffic in a construction zone with no shoulder available for me to get off highway). As I often pull RV's to the far west, it greatly concerns me as to what the outcome would be if this happens while on a 6% downgrade in the mountains. I have had three injector failures recently.