One problem related to gas recirculation valve (egr valve) has been reported for the 2000 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Ford F-150 based on all problems reported for the 2000 F-150.
Spark plugs that were supposed to last 100,000 miles ( motorcraft platinum) lasted under 55,000 miles. The plug separated from the insulator, one even disintegrated, causing misses in the engine and all the wires to the plugs to melt and adhere to what was left of the plugs. 6 plugs - 6 cylinders.