One problem related to ignition module has been reported for the 2006 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Ford F-150 based on all problems reported for the 2006 F-150.
Went to start truck and engine would crank but would not fire. I tried the starting fluid test to see if it was an ignition problem or fuel problem. Gave a little shot of starting fluid into the intake and then tried to start. Motor acted like it was going to start but never started beings I didn't give it enough starting fluid to start because I'm not a fan of using it. With that I eliminated the ignition had to be fuel. I got on the internet and searched no start problem for 2006 F-150 and found a you tube video of the fuel pump control module rusting out. Went out and dropped spare tire and took the control module off the cross member and noticed the hole corroded through the housing just like the video. I got the upgraded part from a Ford dealer for $163 and installed. Runs fine now. My biggest complaint is Ford knows there's a problem since the have came out with an upgraded control module so why isn't this a recall? I live in a state that temperatures in the winter months can be below 0 degrees fahrenheit and drive an hour one way to work, this could have happened when I was on the road in extreme cold, could of had my two children with me broke down on the side of the road and cold out. Luckily it happened at home but still it was 4 degrees out and laying under my truck taking the module off was not very pleasant. Think this is something that Ford needs to do something about.