One problem related to battery cable has been reported for the 2010 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Ford F-150 based on all problems reported for the 2010 F-150.
"ignition cylinder fell out while driving. While driving my vehicle the ignition cylinder (including my keys) fell out of the steering column. The vehicle kept running, power steering and brakes were still functioning and steering wheel was able to be turned. I pulled over to the side of the road and found the ignition cylinder containing my keys on the floor mat of my vehicle. I was able to drive the vehicle home - however I was not able to turn off the engine with the key after I arrived home. I pulled the negative battery cable to kill the engine. I called dorian Ford and was told this is a common failure and for $375 this could be fixed (per roxanne, service advisor @ dorian Ford). I found this incredible that a service advisor would indicate this is a common failure. This was quite scary for the first few moments when I heard the cylinder fall out and then hit my leg on its way to the floor. My first thought was this is the same scenario that occurred on gm vehicles with the ignition cylinder.