One problem related to transmission noise has been reported for the 2010 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Ford F-150 based on all problems reported for the 2010 F-150.
There is a rattle noise when driving 35-75 mph from the transmission when under load. -2010 F-150 4x4 supercrew.