One problem related to transmission slip out of gear has been reported for the 2010 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Ford F-150 based on all problems reported for the 2010 F-150.
Transmission slips out of gear at times. Occasionally it downshifts and the truck slows down fast, other times it feels like it just slips out of gear altogether into neutral, then the engine rpms go high and the truck slows down. Both times, when the transmission goes back into gear, it creates a large thump sound and the truck jumps, occasionally spinning my tires. This happens both while driving on the road and while driving from a stop sign/light and has happened multiple times since I have owned the truck. At least 10 to 15 times per month.