One problem related to side/rear glass has been reported for the 2016 Ford F-150. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2016 Ford F-150 based on all problems reported for the 2016 F-150.
Rear window spontaneously shattered in driveway. Approximately 30 degrees outside temperature, vehicle was started, rear defrost engaged, driven approximately 1/2 block to another driveway. When leaving driveway to enter roadway, rear window shattered with a loud pop. No internal or external impact to the rear window to cause the glass to shatter. No other cars, people, work equipment, mowers, etc were present. My safety was impacted by the startling, loud noise, glass shards exploding into the cab, visibility was greatly impacted and sub-freezing temperatures were now free to enter the cab with no ability to sustain safe cabin temperature. I am having the glass inspected and replaced. No police involved insurance deductible is higher than replacement cost so they are not involved. There were no warning lights or any sign of symptoms prior to the glass explosion. A quick google search would indicate this is a common and dangerous problem. This is clearly a defect in either the glass itself or the rear defrost system. There should be a safety recall before people are hurt or killed by this defect.