One problem related to brake fluid leak has been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
Was pulling my boat out of the water and when stopping heard a loud bang. Stopped truck and saw fluid leaking on to the ground from just forward of the drivers side rear tire. Found fluid to be brake fluid. Brake steel line that runs down the left frame rail had burst near fuel tank. This area hard to see unless using a mirror and light. The brake line was very corroaded and had rusted thru in the area that is hardest to see. Replaced the steel brake line to repair. I am the orignal owner of this truck. I have pictures and have the old brake line.