One problem related to engine rattling and whining sounds has been reported for the 2001 Ford F-250. The most recently reported issues are listed below.
The contact owns a 2001 Ford F-250 sd. The contact stated that while driving approximately 17 mph, he heard an abnormal whining sound. The contact stopped the vehicle and upon inspection, noticed that the spark plugs had blown from the cylinder head. The manufacturer was made aware of the failure. The vehicle was not repaired. The approximate failure mileage was 207,885.