One problem related to engine has been reported for the 2009 Ford F-250. The most recently reported issues are listed below.
During wet weather conditions (humidity and rain especially) and after approximately 30-40 minutes of steady state driving on at freeway speeds; the truck will hesitate when the accelerator pedal is pressed to the floor. The engine rpm will increase with the transmission downshift, then the engine rpm will immediately fall back down by about 500 rpm for approximately 5-7 seconds before returning to a full thottle engine speed. During this time of rpm fluctuation it feels/sounds like a stumble and/or miss in the engine. This is a common occurrence and when weather conditions are as described above can be duplicated easily. This issue is of real concern when merging into traffic or attempting to pass another car. The truck feels like it is going to accelerate into traffic, then all of a sudden momentarily looses power leaving the driver and passengers of the truck vulnerable to a collision with another vehicle. So far my truck has been to the Ford dealership multiple time for multiple days. They have not been able to cure the problem. They have hookup up vehicle data recorders multiple time without success. They did find inconsistencies in the map sensor readings which was subsequently replaced, however the problem persists.