One problem related to front suspension wheel bearing has been reported for the 2000 Ford F-350. The most recently reported issues are listed below.
Ford f350 super duty crew cab: while driving the inner and outer axle bearing seals blew out, along with the hub bearing on the front drivers side. The wheel turned in and appeared as if it would come off. Upon inspection, the passenger side inner and outer seals were also hanging out. Contacted Ford and they said that there was no recall or service bulletin on the truck. They will not help out in any way. There is another report on this web site of the same incidence. Our friend who owns the same year f350 checked his truck to find the exact problem, the seals on the axle bearings are hanging out!.