One problem related to coolant leaking has been reported for the 2005 Ford F-450. The most recently reported issues are listed below.
Vehicle billowing white smoke when started. Not drivable. Towed to recommended local truck repair company. Much testing including cylinder heads themselves. #7 cylinder pushing coolant. Head gasket showing signs of leaking. Replaced. A month in shop. $4,000 repair bill. Ford needs to take responsibility for frequency of this issue at low mileage.