One problem related to engine has been reported for the 2005 Ford F-450. The most recently reported issues are listed below.
While driving our F-450 truck pulling our 6 horse trailer, has several times, had the engine just quit while traveling down the highway at 70mph. Barely getting it off the road safely with a load of horses. Ford has repeatedly replaced injectors, which they claim being the problem, but it has recurred 3 more times. Does it take a death before the problem is remedied? this has happened 3 times previously.