One problem related to rear suspension has been reported for the 2003 GMC Sierra. The most recently reported issues are listed below.
Passenger's side rear suspension vibrated while driving at any speed, resulting in the passenger side tire developing bulges. Passenger's side tire was replaced, and the other tires were rotated. The failure recurred on passenger's side rear tire.
| Suspension problems | |
| Front Suspension Wheel Bearing problems | |
| Front Suspension Hub problems | |
| Rear Suspension problems |