Two problems related to axle assembly have been reported for the 2001 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Honda Odyssey based on all problems reported for the 2001 Odyssey.
At 83,000 miles the second transmission on my 2001 Honda Odyssey failed (registered in my wife's name, lynn roessler). Original transmission failed at 43,000 miles in 2003 and was replaced by Honda under warranty. In July 2005 the second transmission began to slip, check engine light came on, d4 light began to blink, tcs light came on. Returned call to Honda dealer, who again replaced transmission and left inboard joint. I do not know if I have now have a new or rebuilt transmission. I am concerned that the two transmissions I have had so far have lasted, on average, about 41,000 miles.
Front axle broke unexpectedly.