One problem related to noises during shifting has been reported for the 2006 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Honda Odyssey based on all problems reported for the 2006 Odyssey.
2006 Honda Odyssey minivan. While cruising (not accelerating, not climbing) at about 70 mph on I-5 south in southern California, the driver saw the tachometer suddenly shoot up above the red line (>5000 rpm). The engine continued to rev with accompanying very loud engine noise. The engine would not downshift even as the driver eased off the gas pedal. The driver pulled to the side of the freeway and shut the engine off. The undercarriage and back of the car was soaked with transmission fluid. The car was surrounded by the smell of burning oil. The car was towed 129 miles to a service station. Diagnosis: "blown transmission", apparently a recurrent problem with Honda Odysseys.