One problem related to gas recirculation valve (egr valve) has been reported for the 2006 Mercedes Benz E350. The most recently reported issues are listed below.
The main wiring harness for the engine, lighting, fuel injection and rest of critical functions of the vehicle has disintegrated due to a manufacturing defect. The manufacturer has used an inferior and unsuitable insulation for the wires, which, is brittle, cracking and falling off exposing bare wires, creating an extremely hazardous situation. The wire insulation deterioration is causing the wires to short and prevents the vehicle from functioning correctly. This is creating a serious safety hazard. (possible, fire in engine, etc). Due to the seriousness, I recommend the national highway traffic safety administration order the manufacture to properly investigate and issue a safety recall. The manufacturer is aware of this widespread defect but refuses to order a recall. I purchased this vehicle new and operated it under normal conditions. The vehicle has been regularly serviced and maintained by Mercedes Benz authorized dealers since it was new. The vehicle has been well kept and maintained. Your assistance would be greatly appreciated! thank you! gregory chassin.