One problem related to transmission failure has been reported for the 2007 Mercedes Benz E350. The most recently reported issues are listed below.
No warning of any kind, nor any event of any kind. One minute, everything is fine. The next, the transmission fails. Transmission failure has happened 3 times in the past 10 months. Car is a 2007 mercedes. On all 3 occasions, I was driving on multiple lane interstate. One 2 of the incidents, the car suddenly went out of the drive gear into what felt like neutral. It stayed there for 10 or 15 seconds and then resumed in drive on it's own. Possible consequences of very serious accident. On the 3rd incident, I was at a stoplight and when starting on the green light, the car would not come out of 1st gear. Just dropped car off today for this and don't know results yet. What was done to correct: on both of the first 2 occasions, software was updated. There were other things done which bizarrely somehow relate to the transmission. I have no parts. I believe I do have the service sheet from both of the earlier incidents.