One problem related to transmission not go into gear has been reported for the 2007 Mercedes Benz E350. The most recently reported issues are listed below.
When accelerating from a stop light, the car would not shift gears automatically. The car seems to be stuck in 1st gear or neutral as I could not get past 20mph without maxing out my rpm's. I had to drive 3 miles going 20mph to get somewhere so I could get towed. After towed to the dealership, they could not replicate the situation. This has happened twice within a week's time. This is a mercedes 2007 E350. I have seen other posts about this exact same thing with no solution. The dealership said to pull over and restart the car. What!!! what kind of fix is that? I do that to my home pc. . . I shouldn't have to do that for my car! I bought this car less than 30 days ago. . . And the dealership doesn't seem to want any part of it. I haven't even made the first payment or recieved my permanent tags yet.