general problems of the 2010 Mercedes Benz E350

Ten problems related to engine and engine cooling have been reported for the 2010 Mercedes Benz E350. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Mercedes Benz E350 based on all problems reported for the 2010 E350.

1 Engine And Engine Cooling problem

Failure Date: 07/24/2025

Fast acceleration then slow down goes into limp mode . Happens when passing a car or taking off fast like entering into traffic . Very dangerous. Will be calling Mercedes Benz tomorrow. Bought car used approximately 4 months ago. Thanks.

2 Engine And Engine Cooling problem

Failure Date: 04/04/2025

Does the engine in this car have a correct balance shaft?.

3 Engine And Engine Cooling problem

Failure Date: 03/07/2025

Smell gasoline on driver side. Can’t fill tank up or the smell is unbearable. Gas consumption is high. Engine light is on , suspension make a lot of noise, and ticking on driver side.

4 Engine And Engine Cooling problem

Failure Date: 02/10/2025

The contact owns a 2010 mercedes-benz E350. The contact stated while driving at an undisclosed speed, the low battery warning light illuminated. The vehicle was driven to a nearby parking lot. The contact parked the vehicle and opened the hood. The contact stated that upon inspecting the vehicle, the contact noticed pieces of the serpentine belt on the engine. The contact turned the vehicle off. The contact went to a nearby auto parts store and purchased a new serpentine belt. The contact replaced the serpentine belt, and the vehicle was driven to the residence. The contact stated that upon checking the data on the instrument panel, the contact became aware of several error messages. In addition, the contact stated that while driving at an undisclosed speed, the steering wheel failed to turn in the intended direction. The contact stated that the steering wheel had seized. The contact turned off the vehicle and the steering wheel functionality returned. The contact stated that the low coolant warning light illuminated; however, the coolant level was checked and was sufficient. Additionally, the contact stated that the drive assist warning light was illuminated on the instrument panel. The vehicle was taken to two independent mechanics regarding the drive assist warning light; however, the failure could not be duplicated. The vehicle was not diagnosed or repaired by an independent mechanic or the dealer. The manufacturer was made aware of the failure. The failure mileage was approximately 183,000.

5 Engine And Engine Cooling problem

Failure Date: 08/06/2024

August 2024, while driving on a 4 lane highway at 65 mph, a warning appeared on gauge cluster saying that electronic stability control and traction control inoperable. This caused the car to reduce power, requiring me to quickly pull over. The car continued running but I was limited on mph and gear selection (aka limp mode). I turned the car off, allowing the systems to reset. After driving approximately 1 miles, the same warnings appeared. Fortunately, I was within a mile from home at the time so I was able to "limp" the car home. The next day, I checked the car again by driving in my neighborhood with the result. I had the car transported on roll back to express oil and tire in barboursville, wv as my "local" mb dealer is an hour away. They checked the car and the engine control module was defective and needed replacement. The cost of the service including new mb parts and programming would be $2,495. I tried for 2 months to secure funding to fix the car to no avail. I had the car towed on roll back again but back to my house. The car has sat since then.

6 Engine And Engine Cooling problem

Failure Date: 03/07/2024

Smell gasoline when tank get filled up. Engine light is on , suspension make a lot of noise , power steering pump also.

7 Engine And Engine Cooling problem

Failure Date: 10/01/2022

The contact owns a 2010 mercedes-benz E350. The contact stated that the engine was misfiring and shifted limp mode. The contact stated that the check engine warning light was intermittently illuminated. The vehicle was not diagnosed or repaired. A dealer was not contacted. Upon investigation, the contact associated the failure with NHTSA campaign number: 22v168000 (exterior lighting, electrical stability control, engine, and engine cooling) however, the VIN was not included. The manufacturer had been informed of the failure. The failure mileage was approximately 127,000.

8 Engine And Engine Cooling problem

Failure Date: 09/01/2016

We brought this vehicle from 3rd party. Transmission gear sound is coming so hard. I have very low mileage only 48k. I wen to delar, he told me to change the transmission or contact head office to resolve this issue. I need someone to help me for next step.

9 Engine And Engine Cooling problem

Failure Date: 01/13/2016

During cold engine starting, a knocking can be heard in the engine. The knocking lasts approximately eight rotations, and then stops.

10 Engine And Engine Cooling problem

Failure Date: 08/07/2014

Another car made an illegal u-turn and caused me to t-bone on his passenger side. Front of my car hit his passenger side and dragged his car for about 10 feet. Air bags on my car did not deploy, safety system m-brace in car failed and did not call sos either. Car safety system did not detect the crash at all. Mercedes benz did not detect a crash.


Other Engine And Engine Cooling related problems of the 2010 Mercedes Benz E350


E350 Service Bulletins
E350 Safety Recalls
E350 Defect Investigations