One problem related to axle shaft has been reported for the 2006 Nissan Frontier. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Nissan Frontier based on all problems reported for the 2006 Frontier.
2006 Nissan Frontier rear brake failure due to leak in the rear axle shaft. The seals in the rear axle failed allowing oil to completely coat the rear brakes on both sides rendering them essentially useless. Repair required complete replacement of rear axle shaft since Nissan will not replace just the seals. Had repair completed by the same dealership that I purchased the truck from. Nissan paid a portion, but it didn't even cover half of the parts, let alone the labor. I footed the majority of the bill.