One problem related to wiring has been reported for the 2004 Nissan Murano. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2004 Nissan Murano based on all problems reported for the 2004 Murano.
I own a Nissan Murano and in may 08 driving on the freeway and without any warning we had a sudden loss of power. We managed to pull over, stopped the engine and restarted it. Check engine light came on but we were going out of town and car drove fine and check engine light went off. We had the same problem on 9/6/08 and took the car to Nissan dealership. They claim it was a wiring problem to the throttle connection and repaired it and assured me they had fixed the problem. Driving home on an extremely busy freeway in rush hour it happened again, today 9/25 and this time the car behind me had to swerve to avoid me but I was near my exit and cruised to a stop. I was quite shaken. I turned the car off and it started again and immediately drove it to the dealership. They still have it and are checking it. This is an extremely dangerous situation. I have called Nissan and they apparently do not have any complaints and also the dealership has not heard of this which is quite surprising as literally hundreds of complaints regarding the Murano for same problem on websites. My complaint is that the 2004 Nissan Murano (less than 37,000 miles) is extremely dangerous to drive and Nissan knows there is a problem and they are ignoring it. We have been lucky that we were not rear-ended at high speeds where someone could have been killed. I am waiting to hear back from Nissan but the fact that the dealership has not heard of this problem is amazing, just type in Nissan Murano sudden loss of acceleration and you will see. Not sure if anything can be done, but I want my complaint documentation in case someone dies due to this problem.