One problem related to universal joint has been reported for the 2006 Nissan Pathfinder. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2006 Nissan Pathfinder based on all problems reported for the 2006 Pathfinder.
My vehicle started (Mar 2010) to vibrate at between 45 and 65 mph, it felt like I was going over a rumble strip. Brought it to dealer they diagnosed a bad universal joint. Ten months (Jan 2011) later it happened again, additionally car was shifting poorly and felt like it couldn't find the correct gear between 45 and 65 mph, dealer said I need a new transmission. When they dropped the driveshaft they said it was just a universal joint between the transmission and the driveshaft. The problem recurred in Mar 2012, brought vehicle to local mechanic (vehicle was no longer under warranty) who consulted a transmission shop. Was told that radiator fluid was leaking into transmission through a faulty hose/line in the radiator and vehicle now need a transmission overhaul and new radiator. I am concerned that transmission could fail catastrophically on highway leading to an accident and injury.