One problem related to brake disc pads has been reported for the 2010 Toyota Sienna. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2010 Toyota Sienna based on all problems reported for the 2010 Sienna.
Brakes were inspected at tire rotation in December 2012 by local trusted mechanic. Brakes checked good and had approximately 10,000 miles remaining. On January 20, 2013 family returned home from a 3 hour drive to the smell of burning coming from the right rear tire. Tire rim was noted to be as black as the rubber of the tire. Wispy smoke was seen rising from the right rear rotor/brake pads. Extremely hot to touch. On January 21 ,2013 brakes were examined by same mechanic and pads were destroyed. Rotor was also damaged. Causal factor could not be determined. Both rotor and pads replaced and brake fluid drained and refilled. On January 23, 2013 situation returned with right rear tire. The smell of "hot brakes" was coming from the tire and rim was very hot to touch. New rotor shows excessive scarring.