One problem related to constant velocity joint has been reported for the 2000 Chevrolet S10. The most recently reported issues are listed below.
Rubber boot cover broke and caused loss of lubricant around right side cv joints, which have broken and disconnected. Vehicle towed to dealer for repairs. A hole was poked in the cv driver axle boot. This caused it to lose grease and bind the wheel. This incident was a result of poor design and very dangerous flaw.