One problem related to manifold/header/muffler/tail pipe has been reported for the 2000 Chevrolet S10. The most recently reported issues are listed below.
Driving down hill at approximately. 10 mph in first gear, using engine compression to help hold speed down, check engine light came on followed in several seconds by loud explosion and black smoke from engine compartment. Engine died, and power assist for brakes and steering failed. Managed to get truck off street and stopped. Intake manifold had exploded, damaging most of engine compartment contents on right side of motor, as well as most of wiring and tubing on right side of motor.