One problem related to engine has been reported for the 2008 Chrysler 300. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2008 Chrysler 300 based on all problems reported for the 2008 300.
Odometer has 42,000. 00 miles. Car was running fine at 2,200 rpms (on highway, 70 mph with cruise control on) when out of no where I heard a faint knocking from the engine. Before I could get off at the next exit the knock was extremely loud. Before I could get home (3 miles) the engine seized. The oil was changed 700 miles ago and the oil level was full at the time of the incident.