One problem related to engine and engine cooling has been reported for the 2001 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-250 based on all problems reported for the 2001 E-250.
Was driving my 2001 Ford e250 vortec v8 at approx. 30 mph when a spark plug blew out of the engine. An hour and a half away from home , in a not so good area of town. I was left stranded. 120,000 miles on odometer.