One problem related to engine has been reported for the 2001 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-250 based on all problems reported for the 2001 E-250.
I own a 2001 f250 Ford with an 5. 4l gas engine . The rear passenger side spark plug blew out breaking ignition coil causing small fire . The threads were gone and heads must be replaced on vehicle.