One problem related to manifold/header/muffler/tail pipe has been reported for the 2001 Ford E-250. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2001 Ford E-250 based on all problems reported for the 2001 E-250.
I started to hear exhaust noise on my 2001 Ford f250 super duty with a v10 engine with only 53,000 miles. In checking, I found that the bolts that were hold the exhaust manifold to the engine were breaking off at the cylinder head. 6 out off 10 cylinders had broken bolts and the other 4 were near breaking. There is a danger of fire in the engine due to the hot exhaust gases. The repair is very expensive due to having to remove the bolt studs still in the engine head without doing any damage .