Two problems related to tire bead have been reported for the 2000 Ford F-250. The most recently reported issues are listed below.
With less than 10,000 miles on the truck, I have had two of the tires break beads, causing the tires to loose their air pressure. Neither time caused major damage to the tire, or to the vehicle, but they have proved to be unreliable, and possibly dangerous. I have heard that they are being looked at for recall, and based on my limited experiences, I would have to agree with the recommendation. I feel very aprehensive every time I get in my truck. (dot number: 008062 tiresize: 265/75r16).
#1 bubbles appeared at about 11000 mi. #2 sidewall blew a flap about 6 in. Long along the bead and tore out the inner fender on the left rear wheel well. #3 tire was replacement for #1 or #2 after about3300 miles noticed vib noticed ridge around circumfrence of tire took to sears and had checked found to be defective. The tires came as original equip on f250 super duty 2000 ,model I've had general tires years ago which bubbled an side wall . ( dot number: ador tire size: l2358516e ).