One problem related to gasoline engine has been reported for the 2003 Ford F-250. The most recently reported issues are listed below.
I was driving on hwy 59 south to home when a spark plug blew out of my 2003 F-250 with 5. 4 motor. Number 3 passenger spark plug blew out, truck only has 53,000 miles on it. Truck was towed to dealership and they acted like they never heard of such but that they had a kit to fix it. Cost to fix was $454. 36, then the told me no warranty on the fix. Plus tow bill of $149. 00 Ford motor company knows of this defect and refuses to do anything!.