One problem related to coolant leaking has been reported for the 2004 Ford F-250. The most recently reported issues are listed below.
While on a recent trip pulling our 5th wheel travel trailer we noticed on several occasions the smell of anti-freeze while under acceleration(up hills, highway merging). Once at the campground we made a visual check for any leaks and none were found, but the coolant reservoir was at the min mark. I filled to max. On the return trip same thing happened. Once home I checked for leaks and none were found but coolant was back to min mark. At no time during the trip did the truck overheat or run any differently than normal. I made an appointment at our local Ford dealership and after they inspected I was told that the turbo had gone south causing an over boost condition that then entered into the combustion chamber and caused the head gaskets to fail. Then I was told that as the head gaskets had failed pressure from the combustion chamber had entered into the coolant system boosting pressure beyond what the pressure relief cap was rated for on the degas(over flow) bottle and spewed anti freeze out of the bottle, which is what we were smelling. The cost for repairs and parts are estimated at 7,000. 00 dollars for a truck that has little over 58,000 miles on it. A call to Ford customer service(chris) and a follow up call from his supervisor at my request, has netted us nothing as Fords stance on this is "there is nothing that Ford will or can do". After some research I see that I am not the only consumer being asked to bear the brunt of Fords mistakes. Apparently every item that I was told that needed to be replaced is a part that a multitude of consumers are having issues with. This is unacceptable. They know they have an issue yet they do nothing, and no one is holding them accountable. If I wanted to sell my truck after it is repaired I'd be lucky to recoup anything as this issue has grown so large that everyone is selling and the value has dropped.