One problem related to gasoline engine has been reported for the 2005 Ford F-250. The most recently reported issues are listed below.
F-250 sd 4x4 short bed pu 5. 4l gas engine 4. 10 rear end lacks power to tow a 5th wheel (7800 lbs. ) up grades on national highways. Vehicle struggles at 45 mph to make the hills engine requires over 4000 rpm to maintain or improve speed. Vehicle gets 6 mpg while towing.