One problem related to tire bubble has been reported for the 2006 Ford F-250. The most recently reported issues are listed below.
Kelly safari trex lt265/70r17 tires are on an Ford f250 truck. Now on second occurrence of tire developing a "bubble" in the sidewall. Tires are less than one year old and have less than 8000 miles on them. First tire developed this problem within two months of purchase. Truck is used to pull a 27 foot travel trailer. Tires were sold with the understanding that they are built for this purpose. First tire was replaced by retailer at no cost. Second tire is being argued over with the retailer. Retailer is attempting to locate a replacement tire.