One problem related to engine failure has been reported for the 2008 Ford F-250. The most recently reported issues are listed below.
The contact owns a 2008 Ford F-250 sd. While driving, the engine failed to respond. The vehicle was towed to an independent mechanic who diagnosed that the engine needed to be replaced due to a crack in the number eight cylinder wall. The vehicle was not repaired. The manufactuer was notified of the failure. The failure mileage was 125,000.