One problem related to engine knocking noise has been reported for the 2011 Ford F-250. The most recently reported issues are listed below.
The contact owns a 2011 Ford F-250. While driving 60 mph, the vehicle vibrated, emitted a knocking noise, and the engine emitted smoke. The contact was able to coast onto the shoulder of the roadway. The vehicle was towed to an unknown dealer to be diagnosed and a failure code for the engine valve was detected. The dealer informed the contact that the engine needed to be replaced. The engine was not replaced. The manufacturer was notified of the failure. The VIN was not available. The approximate failure mileage was 146,000.