One problem related to loud engine noise has been reported for the 2000 Ford F-350. The most recently reported issues are listed below.
Manual transmission pilot bushing malfunctioned; pilot bushing has been replaced at 9000 miles. Consumer has contacted dealer. On several occasions clutch would slip, dealer replced flywheel clutch assembly and transmission seal, after leaving dealer, consumer noted dealer had not put fluid in transmission, 2 u joints and the cam sensor was replaced due to drivetrain vibration, transmission now makes howling noise, engine has a no start condition.