Ford F-450 owners have reported 1 problem related to transmission failure (under the power train category). The most recently reported issues are listed below.
Transmission failure of 4r100 Ford transmission that has been serviced by Ford since 2000 (when bought) and no mention of a factory overheating problem that an upgraded cooler (per TSB) would have avoided.
See
all problems of the 2000 Ford F-450
🔎.