One problem related to axle shaft seal has been reported for the 2000 Honda Odyssey. The most recently reported issues are listed below. Please also check out the statistics and reliability analysis of the 2000 Honda Odyssey based on all problems reported for the 2000 Odyssey.
There was a slight oil leak at the joint of the torque converter and transmission and the seals were replaced. When pulling from a stop sign, the consumer heard a clanking sound in the steering column, the dealer replaced the entire column, also there was a squeak coming form the rear suspension, the problem was determined to be a leak from the rear shock absorber.